Effect of dural inflammatory soup application on activation and sensitization markers in the caudal trigeminal nucleus of the rat and the modulatory effects of sumatriptan and kynurenic acid

نویسندگان

چکیده

Abstract Background The topical inflammatory soup can model the inflammation of dura mater causing hypersensitivity and activation trigeminal system, a phenomenon present in migraineurs. Calcitonin gene-related peptide, transient receptor potential vanilloid-1 receptor, neuronal nitric oxide synthase are important sensitization process there. 5-HT 1B/1D agonists, triptans used as treatment migraine. Kynurenic acid an NMDA antagonist act on structures involved activation. Aim We investigated effect induced dural calcitonin levels caudal nucleus. also tested whether pretreatment with well-known antimigraine drug, such sumatriptan kynurenic acid, compound different mechanism action, affect these changes if their modulatory effects comparable. Material methods After subcutaneous or intraperitoneal adult male Sprague-Dawley rats ( n = 72) was treated its vehicle (synthetic interstitial fluid). Two half four hours later perfusion performed nucleus removed for immunohistochemistry. Results conclusion Inflammatory increased compared to placebo, which attenuated by acid. This suggests involvement receptors neurogenic development thus migraine attacks.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

on the relationship between using discourse markers and the quality of expository and argumentative academic writing of iranian english majors

the aim of the present study was to investigate the frequency and the type of discourse markers used in the argumentative and expository writings of iranian efl learners and the differences between these text features in the two essay genres. the study also aimed at examining the influence of the use of discourse markers on the participants’ writing quality. to this end the discourse markers us...

15 صفحه اول

the analysis of the role of the speech acts theory in translating and dubbing hollywood films

از محوری ترین اثراتی که یک فیلم سینمایی ایجاد می کند دیالوگ هایی است که هنرپیش گان فیلم میگویند. به زعم یک فیلم ساز, یک شیوه متأثر نمودن مخاطب از اثر منظوره نیروی گفتارهای گوینده, مثل نیروی عاطفی, ترس آور, غم انگیز, هیجان انگیز و غیره, است. این مطالعه به بررسی این مسأله مبادرت کرده است که آیا نیروی فراگفتاری هنرپیش گان به مثابه ی اعمال گفتاری در پنج فیلم هالیوودی در نسخه های دوبله شده باز تولید...

15 صفحه اول

the effects of planning on accuracy and complexity of iranian efl students’ written narrative task performance

this study compared the different effects of form-focused guided planning vs. meaning-focused guided planning on iranian pre-intermediate students’ task performance. the study lasted for three weeks and concentrated on eight english structures. forty five pre-intermediate iranian students were randomly assigned to three groups of guided planning focus-on-form group (gpfg), guided planning focus...

15 صفحه اول

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Journal of Headache and Pain

سال: 2021

ISSN: ['1129-2377', '1129-2369']

DOI: https://doi.org/10.1186/s10194-021-01229-3